New research reveals that people who discontinue blockbuster slimming jabs like Wegovy and Mounjaro can put back on lost weight at a significantly accelerated pace than those who stop traditional diet and exercise programs.
Findings released in a prominent medical journal shows that while overweight people can lose substantial amounts of their total mass while using the jabs, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"Users using such drugs must be aware of the potential of rapid rebound weight gain when the treatment is stopped," cautioned researcher Dr. Susan Jebb.
This pace of recovery implies a return to pre-treatment mass within about a year and a half.
Comparing Approaches
The research, which reviewed 37 of studies involving thousands of participants, contrasted the results of these new drugs with older methods.
Scientists point out that individuals who lose weight through diet and exercise typically have a more gradual weight regain—around 0.1 kg a month—post-intervention.
Explaining the Rapid Regain
Doctors propose the mode of action of the jabs is key to understanding the amplified weight return.
These medications imitate a natural hormone called glucagon-like peptide-1, which controls hunger.
"Artificially providing GLP-1 levels several times higher than normal might result in the body to produce less of its endogenous GLP-1, and may also diminish sensitivity to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication leads to appetite is uncontrolled, making excessive eating far more likely."
A Chronic Disease?
Medical guidelines advise the injections for individuals with weight-linked medical conditions, alongside prescribed lifestyle changes.
Many experts contend that, due to the likelihood of relapse, the treatment should be considered long-term.
This opinion is supported by drug manufacturers, who say that the findings "underscore the persistent nature of excess weight," comparing it to managing conditions like diabetes.
User Accounts
People who have come off the medication report a powerful return of cravings.
"It felt as if a trigger that goes on and you're instantly extremely hungry," said one woman.
The struggle is compounded if users have not adopted lasting dietary or behavioural modifications during therapy.
Widespread Interest
Recent estimates show that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand remaining high.
- Adoption is higher among women than men.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
In conclusion, experts caution that while these medications are powerful tools for weight loss, they are not a permanent cure and lasting health benefits hinges on integrated behavioural changes.
